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Students explore both 2D and 3D models of proteins in order to discern the structure of a small protein, the hormone insulin. They connect the structure to its triggering function at a receptor site for the hormone.
Students will be able to:
The insulin protein molecule is characterized by its folding, which is the result of several types of attractions. Write a short paragraph explaining why three different types of attractions are important to the structure and function of the molecule.
There are tens of thousands of different kinds of proteins. Each one has a unique shape and its 3D structure corresponds to its function. The sequence of amino acids, their interactions, and the interactions with the surrounding environment are explored in this activity. Students can explore the four levels of protein structure using 2D and 3D models.
The three or four-tiered structure of proteins is related to their function.
Additional Related Concepts
This activity is closely connected to the Stepping Stone Protein Folding http://molo.concord.org/database/activities/225.html
This in turn is related to a larger (but from an earlier project) set of three activities Protein Shaping http://molo.concord.org/database/activities/159.html.
Last Update: 12/07/2015
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These materials are based upon work supported
by the National Science Foundation under grant numbers
9980620, ESI-0242701 and EIA-0219345
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