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Activity Number
245
Editable
Overview and Learning Objectives
Assessment
Classroom Practice
Central Concepts
Textbook References
Benchmarks and Standards
Extensions and Connections
Additional Info
Activity Credits
Requirements

DNA to Protein Synthesis (a 6 pp introduction)

Interactive, scaffolded model

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This Activity Requires:

  • Java 1.5+ - Java 1.5+ is available for Windows, Linux, and Mac OS X 10.4 and greater. If you are using Mac OS X 10.3, you can download MW Version 1.3 and explore within it instead.

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Overview and Learning Objectives

In this activity, students work with a model that shows the entire process from gene transcription and translation, through protein folding of the newly synthesized protein.

Students will be able to:

  • reason how DNA, a linear polymer made of four different types of monomers (adenine, thymine, guanine, and cytosine), can store the genetic code: information about sequence of amino acids in proteins;
  • describe the processes of translation and transcription;
  • compare the structure, location, and function of RNA and DNA;
  • manipulate the DNA code and observe how it changes the sequence of m-RNA and proteins.

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Assessment

TEST

http://www.concord.org/~barbara/workbench_web/pdf/DNA_to_Protein8.07.pdf

RUBRIC

http://www.concord.org/~barbara/workbench_web/pdf/DNA_to_Protein_Rubric.8.07a.pdf

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Classroom Practice

Solution For Designer Challenge 4:

TTTTTTTTTGATTTTGATTTTGATTTTGATTTTTTTTTT

Solution for page 5:

GATGATGATTTTTTTTTTTTTTTTTTTTTTCATCATCAT

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Central Concepts

Key Concept:

The sequence of nucleotides in the DNA serves as a genetic code, dictating the sequence of amino acids in proteins.

Additional Related Concepts

Biology

  • Genetics

Molecular Biology

  • DNA
  • RNA

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Textbook References

  • Biology (Miller and Levine) Prentice Hall 5th Edition - Unit 2: Chapter 10 - Genes and Chromosomes
  • Biology (Miller and Levine) Prentice Hall 5th Edition - Unit 2: Chapter 7 - Nucleic Acids and Protein Synthesis
  • Biology (Prentice-Hall) New York Edition - Chapter 12: DNA and RNA
  • Biology (Prentice-Hall) New York Edition - Chapter 16: Evolution
  • Biology (Prentice-Hall) New York Edition - Chapter Seven: Cell Structures and Functions
  • Biology: Concepts and Connections (Pearson) 5th Ed. - Chapter 3: The Molecules of Cells
  • Biology: Concepts and Connections (Pearson) 5th Edition - Chapter 10: Molecular Biology of the Gene
  • Biology: Concepts and Connections (Pearson) 5th Edition - Chapter 12: DNA Technology and the Human Genome
  • Biology: Concepts and Connections (Pearson) 5th Edition - Chapter 4: A Tour of the Cell
  • Biology: Exploring Life - Chapter 11: DNA and the Language of Life
  • Biology: The Dynamics of Life - Chapter 11: DNA and Genes
  • BSCS Blue (8th Edition) - Chapter 12: Reproduction
  • BSCS Human - Chapter 12: Gene Action
  • Cell Biology (Pollard and Earnshaw) Saunders 2002 - Chapter 11: Introduction to Nuclear and chromosomal Structure and Function
  • Cell Biology (Pollard and Earnshaw) Saunders 2002 - Chapter 18: Protein Synthesis and Folding in the Cytoplasm
  • Web of Life - Chapter 7: DNA, Genes and Chromosomes

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Benchmarks and Standards

AAAS

  • THE LIVING ENVIRONMENT: CELLS - The genetic information encoded in DNA molecules provides instructions for assembling protein molecules (Full Text of Standard)

NSES

  • Life Science: Heredity Molecular Basis - 1 In all organisms, the instructions for specifying the characteristics of the organism are carried in DNA (Full Text of Standard)

  • Life Science: The Cell - 3 Cells store and use information to guide their functions (Full Text of Standard)

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Extensions and Connections

The flash interactive animation included as a link in this activity stands on its own as a learning tool.

http://molo.concord.org/database/activities/273.html

A logical next activity is Mutations

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Additional Info

Additional Background

  • DNA Interactive (Howard Hughes and Cold Spring Harbor)

http://www.dnai.org/index.htm

Allows students to follow the footsteps of Crick and Watson as they discover DNA. Flash

  • An excellent DNA tutorial done in Chime:

http://www.dnai.org/a/index.html

  • Good DNA links

http://molvis.sdsc.edu/dna/moredna.htm

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Activity Credits

Created by CC Project: Molecular Logic using Molecular Workbench

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Requirements

  • Java 1.5+ - Java 1.5+ is available for Windows, Linux, and Mac OS X 10.4 and greater. If you are using Mac OS X 10.3, you can download MW Version 1.3 and explore within it instead.

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These materials are based upon work supported
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9980620, ESI-0242701 and EIA-0219345

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