Activity Number 248

	Overview and Learning Objectives
	Assessment
	Central Concepts
	Textbook References
	Benchmarks and Standards
	Macro Micro Link
	Activity Credits
	Requirements

Amplification of Biochemical Signals: the ELISA Test

Interactive, scaffolded model

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	Overview and Learning Objectives Students are introduced to the role of molecular shape, weak attractions and charge in biology and biochemistry, and then undertake a simulated Direct ELISA test. Students will be able to: explain the role of molecular shape, van der Waals attractions, and charge in intermolecular attractions; connect these attractions with the antibody/antigen ELISA procedure. connect the enzymatic reaction with amplification of biological signals (production of antibodies). return to top



	Assessment Test http://www.concord.org/~barbara/workbench_web/pdf/ELISA_asses.8.07.pdf Rubric http://www.concord.org/~barbara/workbench_web/pdf/ELISA_rubric8.07bt.pdf return to top



	Central Concepts Key Concept: The shape of molecules affects the way they function. A test for the body's response to intruders can make use of this. Additional Related Concepts Molecular Biology Antibody-antigen Protein Function Protein structure Recognition Physics/Chemistry Van der Waals return to top



	Textbook References Biology (Miller and Levine) Prentice Hall 5th Edition - Unit 2: Chapter 5 - Cell Structure and Function Biology (Prentice-Hall) New York Edition - Chapter Seven: Cell Structures and Functions Biology: Exploring Life - Chapter 31: The Body's Defense System Biology: The Dynamics of Life - Chapter 39: Immunity from Disease BSCS Blue (8th Edition) - Chapter 23 - Immune System return to top



	Benchmarks and Standards AAAS THE LIVING ENVIRONMENT: BASIC FUNCTIONS - The immune system is designed to protect against microscopic organisms and foreign substances that enter from outside the body and against some cancer cells that arise within (Full Text of Standard) THE LIVING ENVIRONMENT: CELLS - The work of the cell is carried out by the many different types of molecules it assembles, mostly proteins (Full Text of Standard) return to top



	Macro Micro Link A connection is made between illness and test for antigens of that illness and a body's immune response -- the antibodies -- to it. return to top



	Activity Credits Created by CC Project: Molecular Workbench using Molecular Workbench return to top



	Requirements Java 1.5+ - Java 1.5+ is available for Windows, Linux, and Mac OS X 10.4 and greater. If you are using Mac OS X 10.3, you can download MW Version 1.3 and explore within it instead. return to top

These materials are based upon work supported
by the National Science Foundation under grant numbers
9980620, ESI-0242701 and EIA-0219345

Any opinions, findings, and conclusions or recommendations expressed in this
material are those of the author(s) and do not necessarily reflect
the views of the National Science Foundation.

Amplification of Biochemical Signals: the ELISA Test

Overview and Learning Objectives

Assessment

Central Concepts

Additional Related Concepts

Textbook References

Benchmarks and Standards

Macro Micro Link

Activity Credits

Requirements