Activity Number 300

	Overview and Learning Objectives
	Central Concepts
	Textbook References
	Activity Credits
	Requirements

Protein Conservation: an View into Proteomics

Interactive, scaffolded model

Go To Activity

Follow the link above to start or download this activity.

This Activity Requires:

Java 1.5+ - Java 1.5+ is available for Windows, Linux, and Mac OS X 10.4 and greater. If you are using Mac OS X 10.3, you can download MW Version 1.3 and explore within it instead.

Test your system to see if it meets the requirements

Important! If you cannot launch anything from this database, please follow the step-by-step instructions on the software page.

Please Note: Many models are linked to directly from within the database. When an activity employs our scripting language, Pedagogica, as do some of the "guided" activities, the initial download may take several minutes. Subsequent activities will not take a long time. See this page for further instructions.

	Overview and Learning Objectives Students review aspects of protein structure and folding and then move to 3D molecules, evaluating the consequences of both conservative and non-conservative substitutions in protein sequences. The activity culminates in a comparison of human, rat and bacterial enzymes; students discuss why it is be important for some regions to be conserved. Students will be able to: • explain the basic forces at work in protein folding • differentiate conservative and non-conservative substitutions in mutations. • compare human, rat and bacterial enzymes and discuss why it is be important for some to be conserved. return to top



	Central Concepts Key Concept: Finding similarities in sequences is greatly aided by computers. Additional Related Concepts Molecular Biology Protein Folding Protein structure return to top



	Textbook References Biology: Concepts and Connections (Pearson) 5th Edition - Chapter 13: How Populations Evolve Biology: Concepts and Connections (Pearson) 5th Edition - Chapter 15: Tracing Evolutionary History Biology: The Dynamics of Life - Chapter 13: Genetic Technology Cell Biology (Pollard and Earnshaw) Saunders 2002 - Chapter 18: Protein Synthesis and Folding in the Cytoplasm Web of Life - Chapter 8: Protein Synthesis return to top



	Activity Credits Created by CC: Molecular Literacy using Molecular Workbench return to top



	Requirements Java 1.5+ - Java 1.5+ is available for Windows, Linux, and Mac OS X 10.4 and greater. If you are using Mac OS X 10.3, you can download MW Version 1.3 and explore within it instead. return to top

These materials are based upon work supported
by the National Science Foundation under grant numbers
9980620, ESI-0242701 and EIA-0219345

Any opinions, findings, and conclusions or recommendations expressed in this
material are those of the author(s) and do not necessarily reflect
the views of the National Science Foundation.

Protein Conservation: an View into Proteomics

Overview and Learning Objectives

Central Concepts

Additional Related Concepts

Textbook References

Activity Credits

Requirements