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Module 11: Protein Function

Overview

In this set of modeling activities students apply their knowledge of structural changes in protein molecules to explore structure-functional relationship in proteins. They work with a model of a short protein, melittin, and with more complex models of various enzymes, investigating protein-to-ligand docking and how small molecules may affect the conformation of a protein and its functional activity.

Activities

Objectives and Goals

Standards

AAAS

THE LIVING ENVIRONMENT:CELLS - Most cells function best within a narrow range of temperature and acidity.

THE LIVING ENVIRONMENT: BASIC FUNCTIONS - The immune system is designed to protect against microscopic organisms and foreign substances that enter from outside the body and against some cancer cells that arise wihin.

THE LIVING ENVIRONMENT: CELLS - The genetic information encoded in DNA molecules provides insructions for assembling protein molecules.

THE LIVING ENVIRONMENT:CELLS - The work of the cellk is caarried out by the many different typess of molecules it asssembles, mostly proteins.

THE LIVING ENVIRONMENT: CELLS - Within every cell are specialized parts for the transport of materials, energy transfer, protein building, waste disposal, information feedback, and even movement.

THE PHYSICAL SETTING: FORCES OF NATURE - There are two kinds of charges, positive and negative,

THE PHYSICAL SETTING: THE STRUCTURE OF MATTER - The rate of reactions among atoms and molecules depends on how ofteen they encounter one anoher, which is affected by the concentration, pressure and temperature of the reacting materials.

NSES.

Life Science: The Cell - Most cell functions involve chemical reactions.

Life Science: The Cell - 1 Cells have particular structures that underlie their functions ...Inside the cell is a concentrated mixture of thousands of different molecules which form a variety of specialized structures that carry out such cell functions as energy production, transport of molecules, waste disposal, synthesis of new molecules, and the storage of genetic material.

Life Science: The Cell - Cell functions are regulated. Regulation occurs both through changes in the activities of the functions performed by proteins and through the selective expression of individual genes. This regulation allows cells to respond to their environment and to control and coordinate celll growth and division.

Physical Science: Chemical Reactions - Catalysts, such as metal surfaces, acceleraste chemical reactions.



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These materials are based upon work supported
by the National Science Foundation under grant numbers
9980620, ESI-0242701 and EIA-0219345

Any opinions, findings, and conclusions or recommendations expressed in this
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